I wouldn't say it's faking. Comic artists (at least in the US) work several times larger than print size and the art gets reduced before going to press. You'd essentially be doing the same thing.
The other benefit to working bigger is that you have more pixels to work with, so visually your lines wind up looking smoother. Especially when you taper lines off, larger resolution means they'll look less clunky. Can't hurt to try, yeah? It might feel weird at first, but keeping your 'zoom' out at 25-50% or whatever feels like your usual screenshot-size on your screen could help.
The other benefit to working bigger is that you have more pixels to work with, so visually your lines wind up looking smoother. Especially when you taper lines off, larger resolution means they'll look less clunky. Can't hurt to try, yeah? It might feel weird at first, but keeping your 'zoom' out at 25-50% or whatever feels like your usual screenshot-size on your screen could help.