If we're talking the Unglued/Unhinged cards, then I'd have to say this one is my favorite. Just because I imagine someone shouting to someone three tables away while using it.
"HEY! HEY YOU. OVER THERE!"
"WHAT?"
"DESTROY THAT!"
"DESTROY WHAT?"
"THAT! DESTROY THAT!"
"WHY?"
"ASS WHUPPIN'!"
"HEY! HEY YOU. OVER THERE!"
"WHAT?"
"DESTROY THAT!"
"DESTROY WHAT?"
"THAT! DESTROY THAT!"
"WHY?"
"ASS WHUPPIN'!"