As with all things, it has to make sense. If it makes sense, I go for it.
In the past, this has meant character death, character possession (my character was possessed by a cursed entity from another plane trapped in a dagger, which meant the mind/soul of my character was killed and the body of the character was taken by the player of the dagger -- and don't you look at me weird, the sentient daggers (there's three of them) are fun as hell to play opposite), mutilation, and amputation.
For Zhi, injury has been a major part of how she developed as a person, from the kink in her tail to a forced abortion (that wrecked her uterus) when she was a teenager that pushed her over the edge from 'potential productive citizen' to 'wreck of a person.' Zhi had wanted to be a mommy. She can't be one now. It still eats at her, and is part of the reason why she's an adrenaline junky and an addict.
My favorite was a guard character with a skin condition that caused him to get itchy under stress (based, of course, off my own experiences with eczema, though his isn't eczema). He's an upright sort, unyielding and unbending, and his ability to ignore the itching when in uniform was, to me, the closest thing to a superpower I've ever written. Though he is often misguided, his attempts to do right and overcome whatever got thrown at him is so fun to write, and a little cathartic for me. Not your typical injury, no, but definitely a condition that causes him major quality of life issues, as well as interfering with his ability to function.
In the past, this has meant character death, character possession (my character was possessed by a cursed entity from another plane trapped in a dagger, which meant the mind/soul of my character was killed and the body of the character was taken by the player of the dagger -- and don't you look at me weird, the sentient daggers (there's three of them) are fun as hell to play opposite), mutilation, and amputation.
For Zhi, injury has been a major part of how she developed as a person, from the kink in her tail to a forced abortion (that wrecked her uterus) when she was a teenager that pushed her over the edge from 'potential productive citizen' to 'wreck of a person.' Zhi had wanted to be a mommy. She can't be one now. It still eats at her, and is part of the reason why she's an adrenaline junky and an addict.
My favorite was a guard character with a skin condition that caused him to get itchy under stress (based, of course, off my own experiences with eczema, though his isn't eczema). He's an upright sort, unyielding and unbending, and his ability to ignore the itching when in uniform was, to me, the closest thing to a superpower I've ever written. Though he is often misguided, his attempts to do right and overcome whatever got thrown at him is so fun to write, and a little cathartic for me. Not your typical injury, no, but definitely a condition that causes him major quality of life issues, as well as interfering with his ability to function.