The whole time zone difference really isn't that much of a big deal in my experience. I've been in a lot of groups made up of both EU and NA players and although there were some players who completely missed each other, it's not like we all work 9 - 5 jobs and can only play in the afternoons, so for the majority of us, our play times were usually overlapped.
I'm an EU player but I chose Balmung, since there's no difference in between EU and NA servers and from the beta I didn't really see any times of inactivity. Also if you go with Balmung or Gilgamesh, where the majority of us live, there's a chance you might miss out on some players or activities because of timezones, but if you go to a completely different server, then you'll definitely miss out on players and activities.
I'm an EU player but I chose Balmung, since there's no difference in between EU and NA servers and from the beta I didn't really see any times of inactivity. Also if you go with Balmung or Gilgamesh, where the majority of us live, there's a chance you might miss out on some players or activities because of timezones, but if you go to a completely different server, then you'll definitely miss out on players and activities.