SWtOR: I'm cheating a little here, since this RP is far from active. But it is still possibly my favourite RP character to date. Darth Ilis, the pureblood Sith Lord. Rather than a cliche'd smirking and snickering/cackling villain, she would be calm and calculative, but also practical. Not a benevolent being by any means, in fact she is quite despicable. But she has a thought out reason for everything beyond just "it's the Sith way".
Dance of Ages (A LARP with a sequel in sight): Setlan "the Shrike". The fire shaman of the Tribe of the Glowing Ember. The setting is post-apocalyptic futuristic. Technology is seen by survivors of the apocalypse to be the cause of it and it is nearly universally shunned. With centuries of avoiding it, people in their primitive tribes all but forget how it works, so phenomenae with hi-tech origins becomes treated with magic and whatnot. Setlan is convinced that mortal strife will yet again provoke the rage of the elemental spirits as it did ages past, and works thus to preserve good diplomatic relations not only in his own tribe, but between every tribe in the nearby area.
Original unnamed setting: Serweyna the vampire assassin and Sarius Calennor, a young wizard. The setting keeps a 30s-40s level of tech accompanied with magic, and a city-state where humans, vamps, werewolves, hags and lizardmen live in relative harmony, in a world where they are very prone to being enemy. Serweyna or "Seri" is the go-to lady for one of the top 3 vampire nobles in the state when he needs someone gone quietly. Little known fact, Seri has a human sister, who is the fiance of Sarius, who despite his dwindling human wizard bloodline only cares that he marries someone he wants to, much to the dismay of his brother who wants to keep the magician bloodline on life support.
Elder Scrolls: Text-based RP and in-game for Skyrim. Depending on the era, Surtur North-Wind, a bombastic, drunkard nord berserker from the three-faction war (online) times, or his much more serious and collected descendant, Ymir, a Stormcloak officer in the Skyrim civil war a thousand years later.
Fallout (chat-based): Alex Carter, leader of the Ebon Covenant, a slowly-but-surely growing faction California-Nevada area. Aging slowed considerably due to mutation. Over 200 years old, while not a ghoul. Chronically ill though. With him, his trustees Edward Thompson, a skilled engineer, Victoria, his "apprentice", Valeria Mikhailova, a young rising new protege with inhuman instincts, and lastly part of his eventual offspring.
Warcraft: *deep inhale*
Lord Kelmith Ravenwood: half-elf forsaken warlock with a small province and army.
Lady Solineria: The aforementioned apprentice and adoptive daughter. More or less lunatic.
Lady Nellie: Kelmith's daughter by blood. Still living, but loyal to her father regardless.
Sgt. Nina "Scorch" Lumere: An army battlemage. Tough shell, but cherishes her unit inside.
Krista Lumere: Aforementioned's older sister. Paladin of the Silver Hand.
Sarah "Sicklewraith" Jademoore: A blind deathstalker in service of the Ravenwoods
Stella Crawford: An archer in Nina's unit. Incredibly pragmatic and still lacking in basic social skills.
Claudine, Wallace and Kira: The Ravenwood pet ravens respectfully
Daros Neilson: A former paladin cursed by a demon. Can manifest some demonic magic.
The Osprey: Ever-changing squad of mercs led by Daros.
Sylvia Lumere: The oldest Lumere sister. A witch dabbling in all magics generally considered foul.
Albert Wellington: A Gilnean militia leader.
Victor Harlington: Aforementioned second-hand man.
Zargath Stonefist: A warsong clan orc warrior.
And everyone else I forgot about. Some are more active than others, I listed many what others probably wouldn't bother to in my place