East-coast highways only let you exit once every 20 miles. So you're pretty much stuck once you get on.
Unless you're going through a city. At that point it's a trade off between highway traffic jams, or inter-city gridlock.
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As an example, here is Philadelphia's archaic road map
https://www.google.com/maps/@39.9515274,-75.1640811,15z
And here is Los Angeles.
https://www.google.com/maps/@34.0541362,-118.2448739,15z
See how much more 'square' LA is? Much easier to navigate.