Creepiest - The Brood Mother from Dragon Age Origins
It's not just the looks, but the realization of what it used to be. I hate Darkspawn.
https://www.miikahweb.com/gfx/screenshots/games/dragon-age-origins19.jpg[/img]
Funniest - Prince Valanar, WotLK
Blizzard acknowledged their own bad writing here in a nod to the "X is just a setback" line by turning this former 2-person quest fight into part of a raid boss.
http://img3.wikia.nocookie.net/__cb20081203050859/wowwiki/images/8/8b/Prince_Valanar_at_Naxxanar.jpg[/img]
Most Epic - John Irenicus, Baldur's Gate II
The whole game itself was one massive build-up to this fight. The writing was superb. Defeating this guy was one of the most fulfilling fights I've ever had.
http://static.giantbomb.com/uploads/scale_small/0/7378/192034-jon1.jpg[/img]
Weakest - King Koopa, Super Mario Brothers
Jump over, touch axe. Enough said.
http://i.ytimg.com/vi/CgKEM8UpF0A/0.jpg[/img]
Most Hated - Kangaxx the Demilich, Baldur's Gate II
Admittedly, this fight is easy once you gather six scrolls of protection from magic, but I died too many times before learning that trick.
http://i.ytimg.com/vi/0jewTDiI_Lw/maxresdefault.jpg[/img]